Digoxin and human pgp

Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. that concomitant rifampin therapy may affect digoxin disposition in humans 25 Apr 2014 Human P-glycoprotein is encoded by the multidrug resistance 1 and other drugs, including digoxin, HIV protease inhibitors, statins, and

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. of compounds out of the brain across the bloodbrain barrier Digoxin uptake

Scand J Clin Lab Invest. 200767(2):123-34. Human intestinal P-glycoprotein activity estimated by the model substrate digoxin. Larsen UL, Hyldahl Olesen L, J Pharmacol Exp Ther. 1992 Nov263(2):840-5. Transport of digoxin by human P- glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1) Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin If rifampin induces intestinal P-gp in humans, and digoxin is transported from apical

The role of intestinal P-glycoprotein in the interaction of digoxin and

Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15109(2):133-7. Lack of interaction of digoxin and P-glycoprotein inhibitors, quinidine and verapamil in human ConclusionsQuinidine and digoxin are both substrates for P-glycoprotein, and In humans, P-glycoprotein was first described in tumor cells, where it

Pgp, expressed in human placental trophoblasts, was shown to be involved in the function of blood-placental barrier 5 and 7. Digoxin and quinidine are 4 Aug 2014 The substrates of P-glycoprotein can be further divided into drugs which are not metabolised in humans, such as digoxin, and those which are