Digoxin and human pgp

Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin elimination. that concomitant rifampin therapy may affect digoxin disposition in humans 4 Aug 2014 The substrates of P-glycoprotein can be further divided into drugs which are not metabolised in humans, such as digoxin, and those which are

Pgp, expressed in human placental trophoblasts, was shown to be involved in the function of blood-placental barrier 5 and 7. Digoxin and quinidine are

J Pharmacol Exp Ther. 1992 Nov263(2):840-5. Transport of digoxin by human P- glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1) 25 Apr 2014 Human P-glycoprotein is encoded by the multidrug resistance 1 and other drugs, including digoxin, HIV protease inhibitors, statins, and Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15109(2):133-7. Lack of interaction of digoxin and P-glycoprotein inhibitors, quinidine and verapamil in human

The role of intestinal P-glycoprotein in the interaction of digoxin and

Recent data point to the contribution of P-glycoprotein (P-gp) to digoxin If rifampin induces intestinal P-gp in humans, and digoxin is transported from apical ConclusionsQuinidine and digoxin are both substrates for P-glycoprotein, and In humans, P-glycoprotein was first described in tumor cells, where it

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. of compounds out of the brain across the bloodbrain barrier Digoxin uptake Scand J Clin Lab Invest. 200767(2):123-34. Human intestinal P-glycoprotein activity estimated by the model substrate digoxin. Larsen UL, Hyldahl Olesen L,